Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-po...
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
About this item
Full title
Author / Creator
Dhandapani, Rahul , Arokiaraj, Cynthia Mary , Taberner, Francisco J. , Pacifico, Paola , Raja, Sruthi , Nocchi, Linda , Portulano, Carla , Franciosa, Federica , Maffei, Mariano , Hussain, Ahmad Fawzi , de Castro Reis, Fernanda , Reymond, Luc , Perlas, Emerald , Garcovich, Simone , Barth, Stefan , Johnsson, Kai , Lechner, Stefan G. and Heppenstall, Paul A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sens...
Alternative Titles
Full title
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
Authors, Artists and Contributors
Author / Creator
Arokiaraj, Cynthia Mary
Taberner, Francisco J.
Pacifico, Paola
Raja, Sruthi
Nocchi, Linda
Portulano, Carla
Franciosa, Federica
Maffei, Mariano
Hussain, Ahmad Fawzi
de Castro Reis, Fernanda
Reymond, Luc
Perlas, Emerald
Garcovich, Simone
Barth, Stefan
Johnsson, Kai
Lechner, Stefan G.
Heppenstall, Paul A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fe4dc2a3ccaf4f5496713ff8538a5861
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe4dc2a3ccaf4f5496713ff8538a5861
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04049-3
