Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
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Author / Creator
Zuo, Bingfeng , Qi, Han , Lu, Zhen , Chen, Lu , Sun, Bo , Yang, Rong , Zhang, Yang , Liu, Zhili , Gao, Xianjun , You, Abin , Wu, Li , Jing, Renwei , Zhou, Qibing and Yin, HaiFang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Treating large established tumors is challenging for dendritic cell (DC)-based immunotherapy. DC activation with tumor cell-derived exosomes (TEXs) carrying multiple tumor-associated antigen can enhance tumor recognition. Adding a potent adjuvant, high mobility group nucleosome-binding protein 1 (HMGN1), boosts DCs’ ability to activate T cells and...
Alternative Titles
Full title
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fe4fbc85947e42be8068f1782617b5b6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe4fbc85947e42be8068f1782617b5b6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15569-2
