Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
About this item
Full title
Author / Creator
Wojtas, Aleksandra M. , Carlomagno, Yari , Sens, Jonathon P. , Kang, Silvia S. , Jensen, Tanner D. , Kurti, Aishe , Baker, Kelsey E. , Berry, Taylor J. , Phillips, Virginia R. , Castanedes, Monica Casey , Awan, Ayesha , DeTure, Michael , De Castro, Cristhoper H. Fernandez , Librero, Ariston L. , Yue, Mei , Daughrity, Lillian , Jansen-West, Karen R. , Cook, Casey N. , Dickson, Dennis W. , Petrucelli, Leonard and Fryer, John D.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To further elucidate the effect of CLU on tau pathology, we utili...
Alternative Titles
Full title
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Authors, Artists and Contributors
Author / Creator
Carlomagno, Yari
Sens, Jonathon P.
Kang, Silvia S.
Jensen, Tanner D.
Kurti, Aishe
Baker, Kelsey E.
Berry, Taylor J.
Phillips, Virginia R.
Castanedes, Monica Casey
Awan, Ayesha
DeTure, Michael
De Castro, Cristhoper H. Fernandez
Librero, Ariston L.
Yue, Mei
Daughrity, Lillian
Jansen-West, Karen R.
Cook, Casey N.
Dickson, Dennis W.
Petrucelli, Leonard
Fryer, John D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fe6771b48e634b8d8a968a11735cfc6c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe6771b48e634b8d8a968a11735cfc6c
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-020-01079-1
