Structure guided studies of the interaction between PTP1B and JAK
Structure guided studies of the interaction between PTP1B and JAK
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates. Here we identify PTP1B as an inhibitor of IL-6 and show that, in vitro, it can dephosphorylate all four mem...
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Structure guided studies of the interaction between PTP1B and JAK
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TN_cdi_doaj_primary_oai_doaj_org_article_fe7ce3bae9694500a0f1ccbffabd3899
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe7ce3bae9694500a0f1ccbffabd3899
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-05020-9
