LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 s...
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
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Author / Creator
Schelker, Roland C. , Fioravanti, Jessica , Mastrogiovanni, Fabio , Baldwin, Jeremy G. , Rana, Nisha , Li, Peng , Chen, Ping , Vadász, Timea , Spolski, Rosanne , Heuser-Loy, Christoph , Slavkovic-Lukic, Dragana , Noronha, Pedro , Damiano, Giuseppe , Raccosta, Laura , Maggioni, Daniela , Pullugula, Sree , Lin, Jian-Xin , Oh, Jangsuk , Grandinetti, Patrick , Lecce, Mario , Hesse, Leo , Kocks, Emilia , Martín-Santos, Azucena , Gebhard, Claudia , Telford, William G. , Ji, Yun , Restifo, Nicholas P. , Russo, Vincenzo , Rehli, Michael , Herr, Wolfgang , Leonard, Warren J. and Gattinoni, Luca
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regulators that could be harnessed to augment stem-like behavior in CD8
+
T cells. Using IFN-γ production as a...
Alternative Titles
Full title
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
Authors, Artists and Contributors
Author / Creator
Fioravanti, Jessica
Mastrogiovanni, Fabio
Baldwin, Jeremy G.
Rana, Nisha
Li, Peng
Chen, Ping
Vadász, Timea
Spolski, Rosanne
Heuser-Loy, Christoph
Slavkovic-Lukic, Dragana
Noronha, Pedro
Damiano, Giuseppe
Raccosta, Laura
Maggioni, Daniela
Pullugula, Sree
Lin, Jian-Xin
Oh, Jangsuk
Grandinetti, Patrick
Lecce, Mario
Hesse, Leo
Kocks, Emilia
Martín-Santos, Azucena
Gebhard, Claudia
Telford, William G.
Ji, Yun
Restifo, Nicholas P.
Russo, Vincenzo
Rehli, Michael
Herr, Wolfgang
Leonard, Warren J.
Gattinoni, Luca
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_feb411feca9c417783b76fb6c8d7a885
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_feb411feca9c417783b76fb6c8d7a885
Other Identifiers
ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-024-01915-z
