Single cell census of human kidney organoids shows reproducibility and diminished off-target cells a...
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
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Author / Creator
Subramanian, Ayshwarya , Sidhom, Eriene-Heidi , Emani, Maheswarareddy , Vernon, Katherine , Sahakian, Nareh , Zhou, Yiming , Kost-Alimova, Maria , Slyper, Michal , Waldman, Julia , Dionne, Danielle , Nguyen, Lan T. , Weins, Astrid , Marshall, Jamie L. , Rosenblatt-Rosen, Orit , Regev, Aviv and Greka, Anna
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge. Here, we profile four human iPSC lines for a total of 450,118 single cells to show how organoid composition and developmen...
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Full title
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
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TN_cdi_doaj_primary_oai_doaj_org_article_fec9d1d79cc3436c8e6951c9b267d13d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fec9d1d79cc3436c8e6951c9b267d13d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13382-0
