A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesi...
A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1–FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial‐specific deletion of either MST1 or FOXO1 leads to the los...
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Full title
A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_ff05290b95594556b9afa965bdd2d71b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ff05290b95594556b9afa965bdd2d71b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08773-2
