NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in S...
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
About this item
Full title
Author / Creator
Johnson, JP , Focken, Thilo , Khakh, Kuldip , Tari, Parisa Karimi , Dube, Celine , Goodchild, Samuel J , Andrez, Jean-Christophe , Bankar, Girish , Bogucki, David , Burford, Kristen , Chang, Elaine , Chowdhury, Sultan , Dean, Richard , de Boer, Gina , Decker, Shannon , Dehnhardt, Christoph , Feng, Mandy , Gong, Wei , Grimwood, Michael , Hasan, Abid , Hussainkhel, Angela , Jia, Qi , Lee, Stephanie , Li, Jenny , Lin, Sophia , Lindgren, Andrea , Lofstrand, Verner , Mezeyova, Janette , Namdari, Rostam , Nelkenbrecher, Karen , Shuart, Noah Gregory , Sojo, Luis , Sun, Shaoyi , Taron, Matthew , Waldbrook, Matthew , Weeratunge, Diana , Wesolowski, Steven , Williams, Aaron , Wilson, Michael , Xie, Zhiwei , Yoo, Rhena , Young, Clint , Zenova, Alla , Zhang, Wei , Cutts, Alison J , Sherrington, Robin P , Pimstone, Simon N , Winquist, Raymond , Cohen, Charles J and Empfield, James R
Publisher
Cambridge: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Cambridge: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target Na
V
1.6 channels. Such a molecule provides a precision-medicine approach to target
SCN8A
-related epilepsy syndromes (
SCN8A
-RES), where gain-of-function (GoF) mutations lead to excess Na
V
1.6 sodium current, or other indicati...
Alternative Titles
Full title
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
Authors, Artists and Contributors
Author / Creator
Focken, Thilo
Khakh, Kuldip
Tari, Parisa Karimi
Dube, Celine
Goodchild, Samuel J
Andrez, Jean-Christophe
Bankar, Girish
Bogucki, David
Burford, Kristen
Chang, Elaine
Chowdhury, Sultan
Dean, Richard
de Boer, Gina
Decker, Shannon
Dehnhardt, Christoph
Feng, Mandy
Gong, Wei
Grimwood, Michael
Hasan, Abid
Hussainkhel, Angela
Jia, Qi
Lee, Stephanie
Li, Jenny
Lin, Sophia
Lindgren, Andrea
Lofstrand, Verner
Mezeyova, Janette
Namdari, Rostam
Nelkenbrecher, Karen
Shuart, Noah Gregory
Sojo, Luis
Sun, Shaoyi
Taron, Matthew
Waldbrook, Matthew
Weeratunge, Diana
Wesolowski, Steven
Williams, Aaron
Wilson, Michael
Xie, Zhiwei
Yoo, Rhena
Young, Clint
Zenova, Alla
Zhang, Wei
Cutts, Alison J
Sherrington, Robin P
Pimstone, Simon N
Winquist, Raymond
Cohen, Charles J
Empfield, James R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ff1c4ccf767e411f85c1b12a0db8fe55
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ff1c4ccf767e411f85c1b12a0db8fe55
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.72468
