MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-de...
MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
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England: BMJ Publishing Group Ltd
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English
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England: BMJ Publishing Group Ltd
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BackgroundOne of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating receptor NKG2D on NK and CD8 T cells. This shedding reduces cell surface levels of MICA/B and impair...
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MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
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TN_cdi_doaj_primary_oai_doaj_org_article_ff8ffe1b8bda435d9db38f1f06d4754c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ff8ffe1b8bda435d9db38f1f06d4754c
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/s40425-019-0687-9
