Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
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Author / Creator
Zhou, Weiyin , Sampson, Joshua N. , Yang, Qi , Dagnall, Casey , Hautman, Christopher , Jacobs, Kevin B. , Abnet, Christian C. , Amos, Christopher , Amundadottir, Laufey T. , Arslan, Alan A. , Black, Amanda , Blot, William J. , Brinton, Louise A. , Bueno-de-Mesquita, H Bas , Buring, Julie E. , Canzian, Federico , Carreón, Tania , Chaffee, Kari G. , Chang, I-Shou , Chen, Constance , Chen, Kexin , Cook, Linda S. , Crous Bou, Marta , Cullen, Michael , Davis, Faith G. , De Vivo, Immaculata , Duell, Eric J. , Fan, Jin-Hu , Friedenreich, Christine M. , Gallinger, Steven , Gao, Yu-Tang , Gaudet, Mia M. , Gillanders, Elizabeth M. , Goldin, Lynn , Goldstein, Alisa M. , Henriksson, Roger , Holly, Elizabeth A. , Hoover, Robert N. , Hsiung, Chao A. , Hunter, David J. , Hutchinson, Amy , Johansen, Christoffer , Kim, Hee Nam , Kim, Yeul Hong , Koh, Woon-Puay , Kooperberg, Charles , Krogh, Vittorio , Kurtz, Robert C. , LaCroix, Andrea , Marchand, Loic Le , Li, Donghui , Liao, Linda M. , Lin, Dongxin , Liu, Jianjun , Lissowska, Jolanta , Lu, Lingeng , Malats, Nuria , McNeill, Lorna H. , Melin, Beatrice S. , Mirabello, Lisa , Moore, Lee , Orlow, Irene , Peplonska, Beata , Peters, Ulrike , Petersen, Gloria M. , Pooler, Loreall , Qiao, You-Lin , Rajaraman, Preetha , Riboli, Elio , Rodriguez-Santiago, Benjamin , Savage, Sharon A. , Schwartz, Ann G. , Schwartz, Kendra L. , Wendy Setiawan, Veronica , Severi, Gianluca , Shen, Hongbing , Sheng, Xin , Shin, Min-Ho , Spitz, Margaret R. , Stevens, Victoria L. , Stram, Daniel , Tang, Ze-Zhong , Taylor, Philip R. , Van Den Berg, David , Visvanathan, Kala , Wang, Zhaoming , Wheeler, William , Wiencke, John K. , Wolpin, Brian M. , Wu, Tangchun , Wu, Xifeng , Wu, Yi-Long , Xia, Lucy , Zanetti, Krista A. , Zeleniuch-Jacquotte, Anne , Ziegler, Regina G. , Tucker, Margaret , Dean, Michael C. , Yeager, Meredith and Chanock, Stephen J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autos...
Alternative Titles
Full title
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Authors, Artists and Contributors
Author / Creator
Sampson, Joshua N.
Yang, Qi
Dagnall, Casey
Hautman, Christopher
Jacobs, Kevin B.
Abnet, Christian C.
Amos, Christopher
Amundadottir, Laufey T.
Arslan, Alan A.
Black, Amanda
Blot, William J.
Brinton, Louise A.
Bueno-de-Mesquita, H Bas
Buring, Julie E.
Canzian, Federico
Carreón, Tania
Chaffee, Kari G.
Chang, I-Shou
Chen, Constance
Chen, Kexin
Cook, Linda S.
Crous Bou, Marta
Cullen, Michael
Davis, Faith G.
De Vivo, Immaculata
Duell, Eric J.
Fan, Jin-Hu
Friedenreich, Christine M.
Gallinger, Steven
Gao, Yu-Tang
Gaudet, Mia M.
Gillanders, Elizabeth M.
Goldin, Lynn
Goldstein, Alisa M.
Henriksson, Roger
Holly, Elizabeth A.
Hoover, Robert N.
Hsiung, Chao A.
Hunter, David J.
Hutchinson, Amy
Johansen, Christoffer
Kim, Hee Nam
Kim, Yeul Hong
Koh, Woon-Puay
Kooperberg, Charles
Krogh, Vittorio
Kurtz, Robert C.
LaCroix, Andrea
Marchand, Loic Le
Li, Donghui
Liao, Linda M.
Lin, Dongxin
Liu, Jianjun
Lissowska, Jolanta
Lu, Lingeng
Malats, Nuria
McNeill, Lorna H.
Melin, Beatrice S.
Mirabello, Lisa
Moore, Lee
Orlow, Irene
Peplonska, Beata
Peters, Ulrike
Petersen, Gloria M.
Pooler, Loreall
Qiao, You-Lin
Rajaraman, Preetha
Riboli, Elio
Rodriguez-Santiago, Benjamin
Savage, Sharon A.
Schwartz, Ann G.
Schwartz, Kendra L.
Wendy Setiawan, Veronica
Severi, Gianluca
Shen, Hongbing
Sheng, Xin
Shin, Min-Ho
Spitz, Margaret R.
Stevens, Victoria L.
Stram, Daniel
Tang, Ze-Zhong
Taylor, Philip R.
Van Den Berg, David
Visvanathan, Kala
Wang, Zhaoming
Wheeler, William
Wiencke, John K.
Wolpin, Brian M.
Wu, Tangchun
Wu, Xifeng
Wu, Yi-Long
Xia, Lucy
Zanetti, Krista A.
Zeleniuch-Jacquotte, Anne
Ziegler, Regina G.
Tucker, Margaret
Dean, Michael C.
Yeager, Meredith
Chanock, Stephen J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ff910db139f74f1fb230ff9dacdc3391
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ff910db139f74f1fb230ff9dacdc3391
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11843
