Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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Author / Creator
Melanoma GWAS Consortium , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Lunds Melanomstudiegrupp , EpiHealth: Epidemiology for Health , Lund Melanoma Study Group , Institutionen för kliniska vetenskaper, Lund , Section I , Strategic research areas (SRA) , Lunds universitet , Sektion I , Department of Clinical Sciences, Lund , Surgery (Lund) , Tumörmikromiljö , Profilområden och andra starka forskningsmiljöer , Lund University , Sektion V , Section V , Profile areas and other strong research environments , Kirurgi, Lund , Tumor microenvironment , Duffy, David L. , Zhu, Gu , Li, Xin , Sanna, Marianna , Iles, Mark M. , Jacobs, Leonie C. , Evans, David M. , Yazar, Seyhan , Beesley, Jonathan , Law, Matthew H. , Kraft, Peter , Visconti, Alessia , Taylor, John C. , Liu, Fan , Wright, Margaret J. , Henders, Anjali K. , Bowdler, Lisa , Glass, Dan , Ikram, M. Arfan , Uitterlinden, André G. , Madden, Pamela A. , Heath, Andrew C. , Nelson, Elliot C. , Green, Adele C. , Chanock, Stephen , Barrett, Jennifer H. , Brown, Matthew A. , Hayward, Nicholas K. , MacGregor, Stuart , Sturm, Richard A. , Hewitt, Alex W. , Kayser, Manfred , Hunter, David J. , Newton Bishop, Julia A. , Spector, Timothy D. , Montgomery, Grant W. , Mackey, David A. , Smith, George Davey , Nijsten, Tamar E. , Bishop, D. Timothy , Bataille, Veronique , Falchi, Mario , Han, Jiali and Martin, Nicholas G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including
MTAP
,
PLA2G6
, and
IRF4
, and detect novel SNPs in
KITLG
and a region of...
Alternative Titles
Full title
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Authors, Artists and Contributors
Author / Creator
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Lunds Melanomstudiegrupp
EpiHealth: Epidemiology for Health
Lund Melanoma Study Group
Institutionen för kliniska vetenskaper, Lund
Section I
Strategic research areas (SRA)
Lunds universitet
Sektion I
Department of Clinical Sciences, Lund
Surgery (Lund)
Tumörmikromiljö
Profilområden och andra starka forskningsmiljöer
Lund University
Sektion V
Section V
Profile areas and other strong research environments
Kirurgi, Lund
Tumor microenvironment
Duffy, David L.
Zhu, Gu
Li, Xin
Sanna, Marianna
Iles, Mark M.
Jacobs, Leonie C.
Evans, David M.
Yazar, Seyhan
Beesley, Jonathan
Law, Matthew H.
Kraft, Peter
Visconti, Alessia
Taylor, John C.
Liu, Fan
Wright, Margaret J.
Henders, Anjali K.
Bowdler, Lisa
Glass, Dan
Ikram, M. Arfan
Uitterlinden, André G.
Madden, Pamela A.
Heath, Andrew C.
Nelson, Elliot C.
Green, Adele C.
Chanock, Stephen
Barrett, Jennifer H.
Brown, Matthew A.
Hayward, Nicholas K.
MacGregor, Stuart
Sturm, Richard A.
Hewitt, Alex W.
Kayser, Manfred
Hunter, David J.
Newton Bishop, Julia A.
Spector, Timothy D.
Montgomery, Grant W.
Mackey, David A.
Smith, George Davey
Nijsten, Tamar E.
Bishop, D. Timothy
Bataille, Veronique
Falchi, Mario
Han, Jiali
Martin, Nicholas G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ffdbab560c8441628effd5dbb028717d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ffdbab560c8441628effd5dbb028717d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06649-5
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