Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in o...
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet‐induced obesity.
In vitro
, we show that PIKfyve is critical for the control of mitochondrial fragmentation and hypertrophic and a...
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Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
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TN_cdi_doaj_primary_oai_doaj_org_article_ffde4b6b99b64e4fbcf721fdde0f4a1e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ffde4b6b99b64e4fbcf721fdde0f4a1e
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ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201607096
