A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of tastants. Among 25 functional TAS2Rs encoded in the human genome, TAS2R14 is the most promiscuous, and responds to hundreds of chemically diverse ligands. Here we present the cryo–elect...
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A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
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TN_cdi_doaj_primary_oai_doaj_org_article_ffe236aefc0341b29447e20725da57e1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ffe236aefc0341b29447e20725da57e1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54157-6
