Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice
Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining calcium homeostasis. The osteoclast creates an enclosed space, a lacuna, between their ruffled border membrane and the mineralized bone. They extrude H⁺ and Cl⁻ into these lacunae by the combined action of vesicular H⁺-ATPases...
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Full title
Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice
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TN_cdi_fao_agris_US201301589939
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201301589939
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0811682106
