Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition b...
Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Human fatty acid synthase (hFAS) is a homodimeric multidomain enzyme that catalyzes a series of reactions leading to the de novo biosynthesis of long-chain fatty acids, mainly palmitate. The carboxy-terminal thioesterase (TE) domain determines the length of the fatty acyl chain and its ultimate release by hydrolysis. Because of the upregulation of...
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Full title
Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid
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TN_cdi_fao_agris_US201400069127
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201400069127
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1112334108
