Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethyla...
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
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Author / Creator
McCabe, Michael T , Graves, Alan P , Ganji, Gopinath , Diaz, Elsie , Halsey, Wendy S , Jiang, Yong , Smitheman, Kimberly N , Ott, Heidi M , Pappalardi, Melissa B , Allen, Kimberly E , Chen, Stephanie B , Della Pietra, Anthony III , Dul, Edward , Hughes, Ashley M , Gilbert, Seth A , Thrall, Sara H , Tummino, Peter J , Kruger, Ryan G , Brandt, Martin , Schwartz, Benjamin and Creasy, Caretha L
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the polycomb repressive complex 2 and is overexpressed in many cancers. In B-cell lymphomas, its substrate preference is frequently altered through somatic mutation of the EZH2 Y6...
Alternative Titles
Full title
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Authors, Artists and Contributors
Author / Creator
Graves, Alan P
Ganji, Gopinath
Diaz, Elsie
Halsey, Wendy S
Jiang, Yong
Smitheman, Kimberly N
Ott, Heidi M
Pappalardi, Melissa B
Allen, Kimberly E
Chen, Stephanie B
Della Pietra, Anthony III
Dul, Edward
Hughes, Ashley M
Gilbert, Seth A
Thrall, Sara H
Tummino, Peter J
Kruger, Ryan G
Brandt, Martin
Schwartz, Benjamin
Creasy, Caretha L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_fao_agris_US201400069864
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201400069864
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1116418109
