Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
During apoptosis, hundreds of proteins are cleaved by caspases, most of them by the executioner caspase-3. However, caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity. Here, we identified key lys...
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Full title
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
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TN_cdi_fao_agris_US201400081455
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201400081455
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1200934109
