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Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600128705

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

About this item

Full title

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9517-9522

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Activated macrophages are described as classically activated or M1 type and alternatively activated or M2 type, depending on their response to proinflammatory stimuli and the expression of genetic markers including iNOS, arginase1, Ym1, and Fizz1. Here we report that Akt kinases differentially contribute to macrophage polarization, with Akt1 ablati...

Alternative Titles

Full title

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_fao_agris_US201600128705

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600128705

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1119038109

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