Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostat...
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
About this item
Full title
Author / Creator
Tucci, Paola , Agostini, Massimiliano , Grespi, Francesca , Markert, Elke K , Terrinoni, Alessandro , Vousden, Karen H , Muller, Patricia A. J , Dötsch, Volker , Kehrloesser, Sebastian , Sayan, Berna S , Giaccone, Giuseppe , Lowe, Scott W , Takahashi, Nozomi , Vandenabeele, Peter , Knight, Richard A , Levine, Arnold J and Melino, Gerry
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondingly, the inhibitory effect of p63 on EMT markers and...
Alternative Titles
Full title
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Authors, Artists and Contributors
Author / Creator
Agostini, Massimiliano
Grespi, Francesca
Markert, Elke K
Terrinoni, Alessandro
Vousden, Karen H
Muller, Patricia A. J
Dötsch, Volker
Kehrloesser, Sebastian
Sayan, Berna S
Giaccone, Giuseppe
Lowe, Scott W
Takahashi, Nozomi
Vandenabeele, Peter
Knight, Richard A
Levine, Arnold J
Melino, Gerry
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_fao_agris_US201600129706
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600129706
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1110977109
