High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cµ2, Cµ3, and Cµ4) and to address their roles in IgM o...
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Full title
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation
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TN_cdi_fao_agris_US201600137779
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600137779
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1300547110
