Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophos...
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. We used ¹³C tracers and lipidomics to probe fatty acid metabolism, including desaturation, as a function of oncogen...
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Full title
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
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TN_cdi_fao_agris_US201600137812
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600137812
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1307237110
