Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by h...
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Significance The enzyme transglutaminase 2 (TG2) is the target of autoantibodies characteristic of the gluten-sensitive enteropathy celiac disease, and intact enzyme activity seems to be required for the disease-causing immune response. TG2 activity is regulated through conformational changes. Ca ²⁺ binding is required for enzyme activity, whereas...
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Full title
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange
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TN_cdi_fao_agris_US201600138835
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600138835
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1407457111
