MicroRNA-directed program of cytotoxic CD8⁺ T-cell differentiation
MicroRNA-directed program of cytotoxic CD8⁺ T-cell differentiation
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that deletion or depletion of Dicer in mouse or human activated CD8 ⁺ T cells causes up-regulation of perforin, granzymes, and effector cytokines. Genome-wide analysis of...
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Full title
MicroRNA-directed program of cytotoxic CD8⁺ T-cell differentiation
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Record Identifier
TN_cdi_fao_agris_US201600140539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600140539
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1317191110
