Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity...
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease (PD). Therefore, lowering α-synuclein levels represents a viable therapeutic strategy for the treatment of PD and related synucleinopathies. Here, we report that Polo-like kin...
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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
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TN_cdi_fao_agris_US201600141618
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600141618
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1309991110
