TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation
TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angiogenesis. TAp73-deficient mice have an increased incidence of spontaneous and chemically induced tumo...
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Full title
TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation
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Record Identifier
TN_cdi_fao_agris_US201600145630
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600145630
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1410609111
