Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral r...
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Significance Viral infections still constitute a major health issue. Upon viral infection, interferon (IFN) elicits an antiviral response by activating multiple effector systems. The ubiquitin-like protein ISG15 is strongly induced by IFN and mediates its antiviral effect by being covalently conjugated to cellular and viral proteins. The protease U...
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Full title
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
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TN_cdi_fao_agris_US201600145861
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600145861
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1412881112
