PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Molecular therapies are hallmarks of âpersonalizedâ medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule inhibitors of phosphatidylinositol 3-kinase (PI3K) currently in the clinic induce global transcriptional reprogramming in tumors, with activation of growth factor receptors, (re)phosphorylat...
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Full title
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
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Record Identifier
TN_cdi_fao_agris_US201600201141
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600201141
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1500722112
