AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-D...
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
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Publisher
Basel, Switzerland: S. Karger AG
Journal title
Language
English
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Publication information
Publisher
Basel, Switzerland: S. Karger AG
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Scope and Contents
Contents
Introduction: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can i...
Alternative Titles
Full title
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
Authors, Artists and Contributors
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Record Identifier
TN_cdi_gale_healthsolutions_A635678242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_healthsolutions_A635678242
Other Identifiers
ISSN
1018-2438
E-ISSN
1423-0097
DOI
10.1159/000501637
