Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance
Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance
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Author / Creator
Soh, Junichi , Okumura, Naoki , Lockwood, William W , Yamamoto, Hiromasa , Shigematsu, Hisayuki , Zhang, Wei , Chari, Raj , Shames, David S , Tang, Ximing , MacAulay, Calum , Varella-Garcia, Marileila , Vooder, Tõnu , Wistuba, Ignacio I , Lam, Stephen , Brekken, Rolf , Toyooka, Shinichi , Minna, John D , Lam, Wan L and Gazdar, Adi F
Publisher
Public Library of Science
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Language
English
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Public Library of Science
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Contents
Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. We determined 1) mutational status, 2) copy number gains (CNGs) and 3) relative ratio between...
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Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance
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TN_cdi_gale_incontextgauss_ISR_A472849701
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_incontextgauss_ISR_A472849701
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0007464
