Identification and Characterization of a Leucine-Rich Repeat Kinase 2
Identification and Characterization of a Leucine-Rich Repeat Kinase 2
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Public Library of Science
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Language
English
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Public Library of Science
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Contents
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical to understanding its role in disease aetiology. Since the phy...
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Full title
Identification and Characterization of a Leucine-Rich Repeat Kinase 2
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TN_cdi_gale_incontextgauss_ISR_A473841323
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_incontextgauss_ISR_A473841323
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0013672
