The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradyca...
The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia
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Publisher
Public Library of Science
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Language
English
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Public Library of Science
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Contents
Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P.sub.X receptor agonist) produces modest hypertension in patients (2-3 mmHg in 1-yr trial) as well as acute bradycardia independent of changes in blood pressure. However, the precise receptor sub...
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Full title
The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia
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TN_cdi_gale_incontextgauss_ISR_A477013633
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_incontextgauss_ISR_A477013633
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0052985
