TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha
TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha
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Publisher
Public Library of Science
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Language
English
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Publisher
Public Library of Science
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Contents
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout. We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct targe...
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Full title
TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha
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TN_cdi_gale_incontextgauss_ISR_A789549343
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_incontextgauss_ISR_A789549343
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ISSN
1553-7390
DOI
10.1371/journal.pgen.1011159
