A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase as a Modulator of [beta]-Cat...
A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase as a Modulator of [beta]-Catenin/GSK3 Signaling
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Publisher
Public Library of Science
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Language
English
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Public Library of Science
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Contents
The multi-protein [beta]-catenin destruction complex tightly regulates [beta]-catenin protein levels by shuttling [beta]-catenin to the proteasome. Glycogen synthase kinase 3[beta] (GSK3[beta]), a key serine/threonine kinase in the destruction complex, is responsible for several phosphorylation events that mark [beta]-catenin for ubiquitination and...
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Full title
A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase as a Modulator of [beta]-Catenin/GSK3 Signaling
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TN_cdi_gale_infotracacademiconefile_A472886524
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A472886524
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0006892
