Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membra...
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors
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Author / Creator
Pitcher, J A , Inglese, J , Higgins, J B , Arriza, J L , Casey, P J , Kim, C , Benovic, J L , Kwatra, M M , Caron, M G and Lefkowitz, R J
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic receptor kinase (beta ARK) are markedly enhanced on addition of G protein beta gamma subunits. With a model peptide substrate it was demonstrated that direct activation of the kinase could not account for this effect. G prote...
Alternative Titles
Full title
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors
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Record Identifier
TN_cdi_gale_infotracgeneralonefile_A12561352
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A12561352
Other Identifiers
ISSN
0036-8075
DOI
10.1126/science.1325672
