Camptothecin and Podophyllotoxin Derivatives: Inhibitors of Topoisomerase I and II ??? Mechanisms of...
Camptothecin and Podophyllotoxin Derivatives: Inhibitors of Topoisomerase I and II ??? Mechanisms of Action, Pharmacokinetics and Toxicity Profile
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Auckland: Adis international
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Language
English
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Auckland: Adis international
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Camptothecins represent an established class of effective agents that selectively target topoisomerase I by trapping the catalytic intermediate of the topoisomerase I-DNA reaction, the cleavage complex. The water-soluble salt camptothecin-sodium - introduced in early trials in the 1960s - was highly toxic in animals, whereas the semisynthetic deriv...
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Full title
Camptothecin and Podophyllotoxin Derivatives: Inhibitors of Topoisomerase I and II ??? Mechanisms of Action, Pharmacokinetics and Toxicity Profile
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TN_cdi_gale_infotracmisc_A200506435
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A200506435
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ISSN
0114-5916
DOI
10.2165/00002018-200629030-00005
