Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton...
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing
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Publisher
American Society for Clinical Investigation
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Language
English
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Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
The human epidermis serves 2 crucial barrier functions: it protects against water loss and prevents penetration of infectious agents and allergens. The physiology of the epidermis is maintained by a balance of protease and antiprotease activities, as illustrated by the rare genetic skin disease Netherton syndrome (NS), in which impaired inhibition...
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Full title
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing
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Record Identifier
TN_cdi_gale_infotracmisc_A241894862
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A241894862
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI41440.
