Managing the challenge of chemically reactive metabolites in drug development
Managing the challenge of chemically reactive metabolites in drug development
About this item
Full title
Author / Creator
Park, B. Kevin , Boobis, Alan , Clarke, Stephen , Goldring, Chris E.P , Kenna, David Jones J. Gerry , Lambert, Craig , Laverty, Hugh G , Naisbitt, Dean J , Nelson, Sidney , Nicoll-Griffith, Deborah A , Obach, R. Scott , Routledgem, Philip , Smith, Dennis A , Tweedie, Donald J , Vermeulen, Nico , Williams, Dominic P , Wilson, Ian D and Baillie, Thomas A
Publisher
Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
Nature Publishing Group
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More information
Scope and Contents
Contents
The normal metabolism of drugs can generate metabolites that have intrinsic chemical reactivity towards cellular molecules, and therefore have the potential to alter biological function and initiate serious adverse drug reactions. Here, we present an assessment of the current approaches used for the evaluation of chemically reactive metabolites. We...
Alternative Titles
Full title
Managing the challenge of chemically reactive metabolites in drug development
Authors, Artists and Contributors
Author / Creator
Boobis, Alan
Clarke, Stephen
Goldring, Chris E.P
Kenna, David Jones J. Gerry
Lambert, Craig
Laverty, Hugh G
Naisbitt, Dean J
Nelson, Sidney
Nicoll-Griffith, Deborah A
Obach, R. Scott
Routledgem, Philip
Smith, Dennis A
Tweedie, Donald J
Vermeulen, Nico
Williams, Dominic P
Wilson, Ian D
Baillie, Thomas A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A253845115
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A253845115
Other Identifiers
ISSN
1474-1776
DOI
10.1038/nrcl3408
