Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
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Nature Publishing Group
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English
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Nature Publishing Group
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Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many undesirable side effects (sedation, apnoea and dependence) by binding to and activating the G-protein-coupled μ-opioid receptor (μ-OR) in the c...
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Full title
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
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TN_cdi_gale_infotracmisc_A292088150
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A292088150
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/naturel0954
