Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
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Author / Creator
Tannahill, G. M. , Curtis, A. M. , Adamik, J. , Palsson-McDermott, E. M. , McGettrick, A. F. , Goel, G. , Frezza, C. , Bernard, N. J. , Kelly, B. , Foley, N. H. , Zheng, L. , Gardet, A. , Tong, Z. , Jany, S. S. , Corr, S. C. , Haneklaus, M. , Caffrey, B. E. , Pierce, K. , Walmsley, S. , Beasley, F. C. , Cummins, E. , Nizet, V. , Whyte, M. , Taylor, C. T. , Lin, H. , Masters, S. L. , Gottlieb, E. , Kelly, V. P. , Clish, C. , Auron, P. E. , Xavier, R. J. and O’Neill, L. A. J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation.
Succinate is an innate immunity signal
The bacterial endotoxin lipopolysaccharide activates macrophages, as part of the innate immunity response, by inducing a shift from oxidative to glycolytic metabolis...
Alternative Titles
Full title
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Authors, Artists and Contributors
Author / Creator
Curtis, A. M.
Adamik, J.
Palsson-McDermott, E. M.
McGettrick, A. F.
Goel, G.
Frezza, C.
Bernard, N. J.
Kelly, B.
Foley, N. H.
Zheng, L.
Gardet, A.
Tong, Z.
Jany, S. S.
Corr, S. C.
Haneklaus, M.
Caffrey, B. E.
Pierce, K.
Walmsley, S.
Beasley, F. C.
Cummins, E.
Nizet, V.
Whyte, M.
Taylor, C. T.
Lin, H.
Masters, S. L.
Gottlieb, E.
Kelly, V. P.
Clish, C.
Auron, P. E.
Xavier, R. J.
O’Neill, L. A. J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A326502066
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A326502066
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11986
