Smac mimetics and innate immune stimuli synergize to promote tumor death: produced factors that led...
Smac mimetics and innate immune stimuli synergize to promote tumor death: produced factors that led to cancer cell death in the presence of SMCs (Supplementary Fig. 17a). We also isolated primary macrophages from bone marrow and these macrophages also responded to oncolytic VSV infection in a dose-dependent manner to produce factors
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Nature Publishing Group
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English
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Nature Publishing Group
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Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in phase 1 clinical trials in cancer patients. However, because SMCs act by enabling transduction of pro-apoptotic signals, SMC monotherapy may be efficacious only in the subset of...
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Smac mimetics and innate immune stimuli synergize to promote tumor death: produced factors that led to cancer cell death in the presence of SMCs (Supplementary Fig. 17a). We also isolated primary macrophages from bone marrow and these macrophages also responded to oncolytic VSV infection in a dose-dependent manner to produce factors
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TN_cdi_gale_infotracmisc_A360205754
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A360205754
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1087-0156
DOI
10.1038/nbt.2806
