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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent...

Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A390412224

Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR-122-HSP90

About this item

Full title

Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR-122-HSP90

Publisher

Public Library of Science

Journal title

PLoS pathogens, 2014-10, Vol.10 (10)

Language

English

Formats

Publication information

Publisher

Public Library of Science

More information

Scope and Contents

Contents

Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited therapeutic benefits. Evidence suggests that exosomes can transfer genetic materials between cells; however, their role in HCV infection remains obscure. Here, we show that exosomes isolated from sera of chronic HCV infected patients or supernatants of J6/JFH1-HCV-i...

Alternative Titles

Full title

Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR-122-HSP90

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A390412224

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A390412224

Other Identifiers

ISSN

1553-7366

DOI

10.1371/journal.ppat.1004424

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