PIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Facto...
PIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor
About this item
Full title
Author / Creator
Publisher
Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
Public Library of Science
Subjects
More information
Scope and Contents
Contents
Endosomal sorting is an essential control mechanism for signaling through the epidermal growth factor receptor (EGFR). We report here that the guanine nucleotide exchange factor [alpha]PIX, which modulates the activity of Rho-GTPases, is a potent bimodal regulator of EGFR trafficking. [alpha]PIX interacts with the E3 ubiquitin ligase c-Cbl, an enzy...
Alternative Titles
Full title
PIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A421863088
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A421863088
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0132737
