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Constitutively Active Signaling by the G Protein [beta][gamma]-Subunit Mediates Intrinsically Increa...

Constitutively Active Signaling by the G Protein [beta][gamma]-Subunit Mediates Intrinsically Increa...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A429817306

Constitutively Active Signaling by the G Protein [beta][gamma]-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells

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Full title

Constitutively Active Signaling by the G Protein [beta][gamma]-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells

Publisher

Public Library of Science

Journal title

PloS one, 2015-03, Vol.10 (3)

Language

English

Formats

Publication information

Publisher

Public Library of Science

More information

Scope and Contents

Contents

Signaling by the G[beta][gamma] subunit of Gi protein, leading to downstream c-Src-induced activation of the Ras/c-Raf1/MEK-ERK1/2 signaling pathway and its upregulation of phosphodiesterase-4 (PDE4) activity, was recently shown to mediate the heightened contractility in proasthmatic sensitized isolated airway smooth muscle (ASM), as well as allerg...

Alternative Titles

Full title

Constitutively Active Signaling by the G Protein [beta][gamma]-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A429817306

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A429817306

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0118712

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