CD39 expression identifies terminally exhausted [CD8.sup.+] T cells
CD39 expression identifies terminally exhausted [CD8.sup.+] T cells
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Author / Creator
Gupta, Prakash K , Godec, Jernej , Wolski, David , Adland, Emily , Yates, Kathleen , Pauken, Kristen E , Cosgrove, Cormac , Ledderose, Carola , Junger, Wolfgang G , Robson, Simon C , Wherry, E. John , Alter, Galit , Goulder, Philip J. R , Klenerman, Paul , Sharpe, Arlene H , Lauer, Georg M and Haining, W. Nicholas
Publisher
Public Library of Science
Journal title
Language
English
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Publisher
Public Library of Science
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Scope and Contents
Contents
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted [CD8.sup.+] T cells. [CD8.sup....
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Full title
CD39 expression identifies terminally exhausted [CD8.sup.+] T cells
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Record Identifier
TN_cdi_gale_infotracmisc_A434689160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A434689160
Other Identifiers
ISSN
1553-7366
DOI
10.1371/journal.ppat.1005177
