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R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5

R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A477077393

R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5

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Publication information

Publisher

Public Library of Science

More information

Scope and Contents

Contents

The Wnt/[beta]-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/[beta]-catenin signaling, however, the molecular mechanism of RSPO action is not yet fully understood. We performed an unbiased siRNA screen to identify molecules specifica...

Alternative Titles

Full title

R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5

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Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A477077393

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A477077393

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0040976

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