R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5
R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5
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Author / Creator
Ruffner, Heinz , Sprunger, Joëlle , Charlat, Olga , Leighton-Davies, Juliet , Grosshans, Bianka , Salathe, Adrian , Zietzling, Svenja , Beck, Valérie , Therier, Maxime , Isken, Andrea , Xie, Yang , Zhang, Yue , Hao, Huaixiang , Shi, Xiaoying , Liu, Dong , Song, Qinhui , Clay, Ieuan , Hintzen, Gabriele , Tchorz, Jan , Bouchez, Laure C , Michaud, Gregory , Finan, Peter , Myer, Vic E , Bouwmeester, Tewis , Porter, Jeff , Hild, Marc , Bassilana, Fred , Parker, Christian N and Cong, Feng
Publisher
Public Library of Science
Journal title
Language
English
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Publication information
Publisher
Public Library of Science
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Scope and Contents
Contents
The Wnt/[beta]-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/[beta]-catenin signaling, however, the molecular mechanism of RSPO action is not yet fully understood. We performed an unbiased siRNA screen to identify molecules specifica...
Alternative Titles
Full title
R-Spondin Potentiates Wnt/[beta]-Catenin Signaling through Orphan Receptors LGR4 and LGR5
Authors, Artists and Contributors
Author / Creator
Sprunger, Joëlle
Charlat, Olga
Leighton-Davies, Juliet
Grosshans, Bianka
Salathe, Adrian
Zietzling, Svenja
Beck, Valérie
Therier, Maxime
Isken, Andrea
Xie, Yang
Zhang, Yue
Hao, Huaixiang
Shi, Xiaoying
Liu, Dong
Song, Qinhui
Clay, Ieuan
Hintzen, Gabriele
Tchorz, Jan
Bouchez, Laure C
Michaud, Gregory
Finan, Peter
Myer, Vic E
Bouwmeester, Tewis
Porter, Jeff
Hild, Marc
Bassilana, Fred
Parker, Christian N
Cong, Feng
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A477077393
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A477077393
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0040976