Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
About this item
Full title
Author / Creator
Kent, Lindsey N , Bae, Sooin , Tsai, Shih-Yin , Tang, Xing , Srivastava, Arunima , Koivisto, Christopher , Martin, Chelsea K , Ridolfi, Elisa , Miller, Grace C , Zorko, Sarah M , Plevris, Emilia , Hadjiyannis, Yannis , Perez, Miguel , Nolan, Eric , Kladney, Raleigh , Westendorp, Bart , de Bruin, Alain , Fernandez, Soledad , Rosol, Thomas J , Pohar, Kamal S , Pipas, James M and Leone, Gustavo
Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infrequent, casting doubt on a direct role for E2Fs in dri...
Alternative Titles
Full title
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
Authors, Artists and Contributors
Author / Creator
Bae, Sooin
Tsai, Shih-Yin
Tang, Xing
Srivastava, Arunima
Koivisto, Christopher
Martin, Chelsea K
Ridolfi, Elisa
Miller, Grace C
Zorko, Sarah M
Plevris, Emilia
Hadjiyannis, Yannis
Perez, Miguel
Nolan, Eric
Kladney, Raleigh
Westendorp, Bart
de Bruin, Alain
Fernandez, Soledad
Rosol, Thomas J
Pohar, Kamal S
Pipas, James M
Leone, Gustavo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A487001428
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A487001428
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI87583.
