LSL-Kras.sup.G12D; LSL-Trp53.sup.R172H/+; Ink4.sup.flox/+; Ptf1/p48-Cre mice are an applicable model...
LSL-Kras.sup.G12D; LSL-Trp53.sup.R172H/+; Ink4.sup.flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer
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Public Library of Science
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Language
English
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Public Library of Science
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Pancreatic cancer (PC) accumulates multiple genetic mutations, including activating KRAS mutations and inactivating TP53, SMAD4 and CDKN2A mutations, during progression. The combination of mutant KRAS with a single inactivating TP53, SMAD4 or CDKN2A mutation in genetically engineered mouse models (GEMMs) showed that these mutations exert different...
Alternative Titles
Full title
LSL-Kras.sup.G12D; LSL-Trp53.sup.R172H/+; Ink4.sup.flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer
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TN_cdi_gale_infotracmisc_A491171563
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A491171563
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0176844
