Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
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American Society for Clinical Investigation
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Language
English
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Publisher
American Society for Clinical Investigation
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Contents
Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a hallmark of acute myeloid leukemia (AML) that harbors the FLT3-internal tandem duplication (FLT3-ITD) mutation. While FLT3 inhibitors like sorafenib show initial therapeutic efficacy, resistance rapidly develops through mechanisms that are incompletely understood. Here, we used RNA-S...
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Full title
Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
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TN_cdi_gale_infotracmisc_A523063033
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A523063033
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ISSN
0021-9738
DOI
10.1172/JCI91893.
