Human islets expressing HNF1A variant have defective cell transcriptional regulatory networks
Human islets expressing HNF1A variant have defective cell transcriptional regulatory networks
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Author / Creator
Haliyur, Rachana , Tong, Xin , Sanyoura, May , Shrestha, Shristi , Lindner, Jill , Saunders, Diane C , Aramandla, Radhika , Poffenberger, Greg , Redick, Sambra D , Bottino, Rita , Prasad, Nripesh , Levy, Shawn E , Blind, Raymond D , Harlan, David M , Philipson, Louis H , Stein, Roland W , Brissova, Marcela and Powers, Alvin C
Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained [beta] cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-evoked stimulation. With these unexpected find...
Alternative Titles
Full title
Human islets expressing HNF1A variant have defective cell transcriptional regulatory networks
Authors, Artists and Contributors
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Record Identifier
TN_cdi_gale_infotracmisc_A570046406
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A570046406
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI121994
