MitoTALEN reduces mutant mtDNA load and restores tRNA.sup.Ala levels in a mouse model of heteroplasm...
MitoTALEN reduces mutant mtDNA load and restores tRNA.sup.Ala levels in a mouse model of heteroplasmic mtDNA mutation
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Nature Publishing Group
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English
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Nature Publishing Group
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Mutations in the mitochondrial DNA (mtDNA) are responsible for several metabolic disorders, commonly involving muscle and the central nervous system.sup.1. Because of the critical role of mtDNA in oxidative phosphorylation, the majority of pathogenic mtDNA mutations are heteroplasmic, co-existing with wild-type molecules.sup.1. Using a mouse model...
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MitoTALEN reduces mutant mtDNA load and restores tRNA.sup.Ala levels in a mouse model of heteroplasmic mtDNA mutation
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TN_cdi_gale_infotracmisc_A573111890
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A573111890
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1078-8956
DOI
10.1038/s41591-018-0166-8
